What is pigmentary mosaicism?

Pigmentary mosaicism is a term that describes varied patterns of pigmentation in the skin caused by genetic heterogeneity of the skin cells.

What causes pigmentary mosaicism?

Pigmentary mosaicism is nowadays recognized as a pigmentary disorder caused by somatic chromosomal abnormalities disrupting or accelerating the function of pigmentary genes. Affected individuals with pigmentary mosaicism commonly have multiple congenital abnormalities, developmental delays and/or mental retardation.

Does pigmentary mosaicism go away?

Pigmentary mosaicism is a permanent color change in the skin. We are not able to change the genetic material to make the skin color the same.

Can mosaicism be cured?

There is no cure for T8mS, but some symptoms of the condition may be treated. Treatment will vary depending on symptoms and severity. Symptoms with no associated health problems, such as facial deformities, may be difficult to treat and may require surgery. In some cases, heart surgery is also recommended.

Is vitiligo due to mosaicism?

Clinical findings in vitiligo challenge the widely accepted organ specific autoimmune pathomechanisms. We draw the attention to the fact that the distribution of segmental vitiligo (SV) fits in at least a subset of patients a pattern usually associated with cutaneous mosaicism.

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What is the most common extracutaneous involvement associated with pigmentary mosaicism?

The most frequently reported extracutaneous anomalies were skeletal deformities, seizures, mental retardation, dysmorphic facial features, and developmental delay.

Is vitiligo an illness?

Vitiligo (vit-ih-LIE-go) is a disease that causes loss of skin color in patches. The discolored areas usually get bigger with time. The condition can affect the skin on any part of the body. It can also affect hair and the inside of the mouth.

What is Hypomelanosis of Ito syndrome?

Hypomelanosis of Ito is a rare condition characterized by distinctive skin changes, in which areas of the body lack skin color (hypopigmentation). These skin changes may present as patches, streaks or spiral-shaped (whorled) areas.

What is Hypomelanosis of Ito syndrome genetic mosaic?

Hypomelanosis of Ito is a pigmentary mosaicism characterized by a clone of skin cells with decreased ability to produce pigment. The clinical pattern is characterized by hypopigmented streaks and whorls running along the lines of Blaschko, characteristically involving more than two body segments.

How are pigmentary demarcation lines treated?

Pigmentary demarcation line in pregnancy may regress spontaneously after delivery and does not require treatment. Facial PDL has a persistent course posing cosmetic concern for the patient and a challenge for dermatologist.

Why is mosaicism bad?

Mosaicism can low the accuracy of single cell PGD results. And it can happen even after the biopsy if the embryo was exposed to inadequate conditions. It is unlikely this group of embryo can implant.

What are some examples of mosaicism?

Examples of mosaicism include: Mosaic Down syndrome. Mosaic Klinefelter syndrome. Mosaic Turner syndrome.

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Who discovered mosaicism?

One basic mechanism that can produce mosaic tissue is mitotic recombination or somatic crossover. It was first discovered by Curt Stern in Drosophila in 1936. The amount of tissue that is mosaic depends on where in the tree of cell division the exchange takes place.

What is segmental vitiligo?

Segmental vitiligo is an uncommon form of localized vitiligo, characterized by dermatomal distribution. It is often unilateral and asymmetrical that never crosses the midline of body (1,4,5). In this form of the disease, depigmentation spots spread quickly in the affected dermatomes and then stop growing.

What is hypopigmentation on face?

Hypopigmentation refers to patches of skin that are lighter than your overall skin tone. Your skin’s pigmentation, or color, is based on the production of a substance called melanin. If your skin cells don’t produce enough melanin, the skin can lighten. These effects can occur in spots or may cover your entire body.

How common is nevus Depigmentosus?

The term nevus depigmentosus, however, is a misnomer, because the lesion is hypopigmented but not depigmented. The reported prevalence of nevus depigmentosus varies from 0.4% to 3%.